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As GPX4 serves as the master regulator of lipid hydroperoxide reduction, its suppression triggers irreversible lipid peroxide accumulation that culminates in ferroptotic cell death (67, 68)

In the cytosol, aberrant IRP1 activation increases the labile iron pool through enhanced transferrin-mediated iron import and NCOA4-mediated ferritinophagy

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Ascorbic Acid (Vitamin C, 25,000 mg) Promotes collagen production, brightens tone, and enhances antioxidant defenses

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